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Stres patofyziologie

Stres neboli všeobecný adaptační syndrom, jako méně známý název pro i širokou veřejností často užívaný termín, je stav, který k životu patří. A jak poznamenal autor tohoto výrazu Hans Selye, stres je život a život je stres. Přestože dnes víme, že stres je fylogenetickým vývojem vypracovaná reakce vyšších organismů život zachraňující (promptně. Stress is a state of threatened homeostasis caused by intrinsic or extrinsic adverse forces (stressors) and is counteracted by an intricate repertoir of physiologic and behavioral responses aiming to maintain/reestablish the optimal body equilibrium (eustasis). The adaptive stress response depends u

Stres - příznaky, projevy, prevence a léčba nemocí. Jako stres se označuje reakce na situaci, kdy je organismus vystaven nějaké zátěži, situaci, kterou vyhodnotí jako nebezpečí, kdy hrozí poškození organismu, integrity či identity

Výukový portál Lékařské fakulty v Plzni : Patofyziologie

Exposure to stress results in alterations of the brain-gut interactions (brain-gut axis) ultimately leading to the development of a broad array of gastrointestinal disorders including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and other functional gastrointestinal diseases, food antigen-related adverse responses, peptic ulcer and gastroesophageal reflux disease (GERD) Created by Ryan Scott Patton. Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/processing-the-environment/stress/v/physical-effects-of-stres.. Definice patofyziologie; Zdraví a nemoc; fyzická aktivita, stres), ale vždy jde o multifaktoriální podklad. Hovoříme o určitém nastavení hypotalamického centra hladu a sytosti, do kterého přichází řada impulzů jednak z GIT, ale i smyslových center, které cestou mozkové kůry uvolňují pocity hladu nebo sytosti. Stress is actually a normal part of life. At times, it serves a useful purpose. Stress can motivate you to get that promotion at work, or run the last mile of a marathon. But if you don't get a..

Stress, Endocrine Physiology and Pathophysiolog

Online knihkupectví Knihy.ABZ.cz - aktuální nabídka titulů z kategorie: Knikupectví > Katalog předmětový > S > Stres (fyziologie) PATHOPHYSIOLOGY OF STRESS INCONTINENCE Chapter 27 PATHOPHYSIOLOGY OF STRESS INCONTINENCE Christopher R. Chapple, Francesca Manassero The lower urinary tract provides continence by storing urine at low pressure until it is socially convenient and appropriate to void The stress response begins in the brain (see illustration). When someone confronts an oncoming car or other danger, the eyes or ears (or both) send the information to the amygdala, an area of the brain that contributes to emotional processing. The amygdala interprets the images and sounds. When it perceives danger, it instantly sends a distress.

Jeden panák, a jsi z toho venku! Taky jste to asi na jaře slyšeli. Návod na rychlou domácí léčbu koronaviru ale bohužel takhle nefunguje. Alkohol průběh nemoci spíš komplikuje. Současná situace může být pro některé jedince nešťastná, může se jim zdát, že izolace trvá už. Ústav patologické fyziologie U Nemocnice 5 , Praha 2, 128 53 . DIČ: CZ00216208 IČ: 00216208 tel: +420 224 965 901 fax: +420 224 965 916 e-mail: patfy@lf1.cuni.cz. Stress can also make pain, bloating, or discomfort felt more easily in the bowels. It can affect how quickly food moves through the body, which can cause either diarrhea or constipation. Furthermore, stress can induce muscle spasms in the bowel, which can be painful. Stress can affect digestion and what nutrients the intestines absorb Abstract. Stress injury of bone includes a spectrum from hyperactive bone remodeling to a discrete fracture line visible on imaging. Stress fractures can occur when bone, either healthy or osteopenic, is subject to repeated loading with subsequent failure of normal bone metabolism and remodeling

Patofyziologie-- autor: Nair Muralitharan, Peate Ian Hulínova Patofyziologie-- autor: Hulín Ivan Hypoglykemie-- autor: Škrha Jan. Komentáře ke slovu patofyziologie, patofysiologi The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes. J Nerv Ment Dis . 2013. 201(12):1007-20. Kasai K, Yamasue H, Gilbertson MW. Stres neboli všeobecný adaptační syndrom, jako méně známý název pro i širokou veřejností často užívaný termín, je stav, který k životu patří. A jak poznamenal autor tohoto výrazu Hans Selye, stres je život a život je stres Zaměření pracoviště: Fyziologie a patofyziologie dýchacího systému: ventilační odpověď na hypoxii, regulace funkční reziduální kapacity plic, změny aktivity CNS související s regulací dýchání, úloha plicních žírných buněk v přestavbě plicního řečiště při hypoxii, reaktivita plicních cév, vliv radikálového poškození plicní tkáně v patogenezi.

While prolactin is most well known for its role in lactation and suppression of reproduction, its physiological functions are quite diverse. There are many etiologies of hyperprolactinemia, including physiologic as well as pathologic causes. Physiologic causes include pregnancy, lactation, sleep-associated, nipple stimulation and sexual orgasm, chest wall stimulation, or trauma. Stress is also. Vypracované otázky z patofyziologie, Kuba Holešovský Vzniku mutací zabraňují reparační procesy DNA, případně tzv. zpětné mutace. Ke zvýšené incidenci mutací dochází při defektu v genech kódujících reparační enzymy (mutátorové geny), což je podkladem různých chorob (např. Fanconiho pancytopenie, xeroderma. Pathophysiology of pain and its clinical application The article describes the pathophysiology of both acute and chronic pain. To, že do bolesti je zakomponován i stres, dosvědčuje motorická komponenta, která se uplatňuje zejména v obranném mechanismu proti bolesti (fight or flight - bojuj, nebo uteč) (1, 9) Úvod do preklinické medicíny PATOFYZIOLOGIE Kateryna Nohejlová a kol. Praha Univerzita Karlova v Praze 3. lékařská fakulta 201 Stress incontinence occurs when the tissue that supports your urethra gets weak. The bladder and urethra are supported by the pelvic floor muscles. Urine flows from your bladder through your urethra to the outside. The sphincter is a muscle around the opening of the bladder. It squeezes to prevent urine from leaking through the urethra

Recent studies have shown the possible roles of inflammation along with oxidative stress. Additionally, angiogenesis and apoptosis dysregulation contribute to endometriosis pathophysiology. Therapeutic strategies and continuing attempts, to conquer endometriosis should be done regarding molecular signaling pathways Post-traumatic stress disorder (PTSD) is a mental health condition that's triggered by a terrifying event — either experiencing it or witnessing it. Symptoms may include flashbacks, nightmares and severe anxiety, as well as uncontrollable thoughts about the event Stress, or a general adaptation syndrome, as a less well-known name, is an often used term, and it is a condition that belongs to life. And as the author of this term, Hans Selye said, stress is life and life is stress. Although we now know that stress is a phylogeneticall It is concluded that there are several routes by which poor welfare results in an increase in disease. The pathophysiology of states typified by behavioural abnormalities and emergency physiological responses is a subject which is insufficientl

Stress fractures can occur when bone, either healthy or osteopenic, is subject to repeated loading with subsequent failure of normal bone metabolism and remodeling. Factors that increase load, such as repetitive impact through competition or training during sports or military training, also contribute to the development of a stress fracture Learn pathophysiology stress with free interactive flashcards. Choose from 500 different sets of pathophysiology stress flashcards on Quizlet

Of these, ulceration and bleeding related to stress-related mucosal disease (SRMD) can lengthen hospitalization and increase mortality. The purpose of this review is to discuss the many risk factors and underlying illnesses that have a role in the pathophysiology of SRMD and evaluate the evidence pertaining to SRMD prophylaxis in the intensive. Stress is defined as a state of psychological and physiological imbalance resulting from the disparity between situational demand and the individual's ability and motivation to meet those needs. Dr. Hans Selye, one of the leading authorities on the concept of stress, described stress as the rate of all wear and tear caused by life Stress is a feeling of emotional or physical tension. It can come from any event or thought that makes you feel frustrated, angry, or nervous. Stress is your body's reaction to a challenge or demand Unlike bad stress, or distress, good stress can help with motivation, focus, energy, and performance. For some people, it can also feel exciting. On the other hand, bad stress typically causes.

Hormonal Response. Other than the nervous system, the body's stress response also includes the help of the adrenal glands. Situated on top of each kidney, the adrenal glands are also included in the physiologic stress response because the adrenal medulla (the center part of the glands) has nerves that connect the gland to the SNS MUDr. Zdeněk Pospíšil Seznam přednášek - denní Úvod do patofyziologie, příčiny nemoci Projevy nemoci Buňka, nádory. Růst, vývoj, stárnutí , smrt Imunita, poruchy metabolismu Patofyziologie dýchacího systému Patofyziologie kardiovaskulárního systému Patofyziologie trávicího systému Patofyziologie ledvin Patofyziologie CNS Patofyziologie žláz s vnitřní sekrecí. Oxidative stress (OS) plays an essential role in the pathogenesis of common neurodegenerative diseases. We have previously shown that Toxoplasma gondii (T. gondii) induces high nitric oxide (NO) production, glial activation, and apoptosis that altogether cause severe neuropathology in toxoplasma encephalitis (TE).The objective of this study was to investigate the cytotoxic effect of OS and to. A stress ulcer can cause pain and a burning sensation in the lining of the gut, and these ulcers usually appear with additional symptoms. Treatment includes medications. Learn more about stress. Stress incontinence is the inability to control your urge to urinate in certain circumstances. It's a serious and embarrassing disorder and can lead to social isolation. Any pressure placed on.

Pracovní dny Stručný Průnik infarkt myokardu biochemické

Patofyziologie - Faculty of Sports Studie

{{configCtrl2.info.metaDescription} The stress fracture, first described by Breithaupt in 1855, [] is a common overuse injury seen in athletes and military recruits. [2, 3] The injury is usually seen in the lower extremities, but it has also been reported in the upper extremities and the ribs.The most common locations for stress fractures include the tibia, metatarsals, fibula, and navicular bones; less common locations include. Mitochondrial Stress Pathophysiology MITOLA Patofyziologie jater 1. Ikterus = žloutenka = žluté zbarvení kůže, sliznic a skléry dané zvýšeným množstvím bilirubinu Hyperbilirubinemie - nekonjugovaná= nekonjugovaný bilirubin ˃ konjugovaný, nepřítomnost •stres - ↑ katecholaminy, glukokortikoidy 24. Hyperglykemi

Pathophysiology. Stress-induced hypertension normally constitutes an end point for test termination because of safety concerns. 110 The clinical characteristics of patients with a marked hypertensive response were analyzed in only 3 studies. 12,27,109 Such patients more often had a history of systemic hypertension and higher resting blood. Science and medicine. Stress (biology), an organism's response to a stressor such as an environmental condition Stress (linguistics), relative emphasis or prominence given to a syllable in a word, or to a word in a phrase or sentence Stress (mechanics), the internal forces that neighboring particles of a continuous material exert on each other. The Etiology and Pathophysiology of Stress Ulcers Jon-emile on August 23rd, 2012 - 1:54pm . Great article Dr. Naylor. I just wanted to add a couple of details from the sentinel Cook article you reference (one that everyone seems to forget on ICU rounds). As you mentioned, the risks of bleeding were identified as: 1) Respiratory failure. stress incontinence, pathophysiology, urinary tract, anatomy Search for Similar Articles You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search

Přehled patofyziologie trombofilních stavů a možností

Post-traumatic stress disorder (PTSD) is a disorder that develops in some people who have experienced a shocking, scary, or dangerous event. It is natural to feel afraid during and after a traumatic situation. Fear triggers many split-second changes in the body to help defend against danger or to. The major cause of stress incontinence is urethral hypermobility due to impaired support from pelvic floor. A less common cause is an intrinsic sphincter deficiency, usually secondary to pelvic. Disruptions in homeostasis (ie, stress) place demands on the body that are met by the activation of 2 systems, the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS)

Stres - příznaky a léčb

Patofyziologie deprese: Co se při depresi odehrává v těle? Probíhá výzkum různých aspektů toho, co přesně se v těle děje, když je člověk v depresi. 1. Narušení chemické rovnováhy v mozku - monoaminová hypotéza Bylo zjištěno, že chronický stres působí strukturální změny v mozku Stress-induced gastritis—also referred to as stress-related erosive syndrome, stress ulcer syndrome, and stress-related mucosal disease—can cause mucosal erosions and superficial hemorrhages in patients who are critically ill or in those who are under extreme physiologic stress, resulting in minimal-to-severe gastrointestinal (GI) blood loss and leading to blood transfusion if not.

Stress and the gut: pathophysiology, clinical consequences

Studium medicíny v HK: 2014

www.uptodate.co Stres : Patofyziologie, endokrinologie, klinika -- OLA001 539.094 Katalog Vědecké knihovny v Olomouci, báze SVK01, záznam 000230202 Navigace: https://aleph.vkol.cz/pub / svk01 / 00023xxxx / 0002302xx / 000230202.ht G6PD deficiency is a common, X-linked reduction in the activity of glucose-6-phosphate dehydrogenase (G6PD), which makes erythrocytes susceptible to oxidative stress and usually causes acute hemolytic anemia in response to a trigger. G6PD enzyme deficiency is the most common enzyme defect. Etiolog

Because the heat stress (HS) considered a model of thermal injury to the central nervous system (CNS), the purpose of this review was to assess the histopathological changes of HS on CNS. Also, this review emphasized that the heat stress may retard partially the degree of the postnatal neurogenesis and growth of CNS

Responding to stress Processing the Environment MCAT

Internetové studijní materiály pro studenty českých a slovenských lékařských fakult Laboratoř patofyziologie rostlin. Temporary heat stress suppresses PAMP‐triggered immunity and resistance to bacteria in Arabidopsis thaliana. Janda M., Lamparová L., Zubíková A., Burketová L., Martinec J., Krčková Z. MOLECULAR PLANT PATHOLOGY 2019 (External fulltext

Patofyziologie - fsps

Depression is a serious mood disorder that affects the brain. Know more about the research, causes, symptoms and treatment for major depressive disorder The effects of chronic stress. Your nervous system isn't very good at distinguishing between emotional and physical threats. If you're super stressed over an argument with a friend, a work deadline, or a mountain of bills, your body can react just as strongly as if you're facing a true life-or-death situation Understanding asthma pathophysiology helps you understand how the condition is diagnosed and treated. Our knowledge of asthma pathogenesis has changed dramatically in the last 25 years, as researchers have found various asthma phenotypes. Stress the importance of smoking cessation. Urge patients to receive annual vaccinations, as asthma. Oxidative Stress and Mitochondrial Dysfunction in Human Diseases: Pathophysiology, Predictive Biomarkers, Therapeutic . by Chia-Jung Li. 1,2. 1. Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan. 2 Nearly a quarter of older adults in the U.S. have type 2 diabetes, and this population is continuing to increase with the aging of the population. Older adults are at high risk for the development of type 2 diabetes due to the combined effects of genetic, lifestyle, and aging influences. The usual defects contributing to type 2 diabetes are further complicated by the natural physiological.

Common Causes of Stress & Their Effect on Your Healt

Stress incontinence - Symptoms and causes - Mayo Clini

Study 69 Stress flashcards from Angelica T. on StudyBlue Chronic stress increases the risk of developing health problems including obesity, diabetes, heart disease, cancer, and a weakened immune system. Chronic stress also affects a person's mental. Stress is bumper-to-bumper traffic when you're in a hurry. It's a worrisome illness, an argument with your partner, a job turning sour. It's the need to care for an ailing parent and a pile of unpaid bills. Stress has many faces, and creeps into our lives from many directions. No matter what causes it, stress puts the body and the mind on edge

Brain Physiology and Pathophysiology in Mental Stres

  1. Stress affects us all. You may notice symptoms of stress when disciplining your kids, during busy times at work, when managing your finances, or when coping with a challenging relationship
  2. The amount of stress you feel in different situations may depend on many factors such as: your perception of the situation - this might be connected to your past experiences, your self-esteem, and how your thought processes work (for example, if you tend to interpret things positively or negatively
  3. Patofyziologie GIT Michal Procházka Klinika RHB a TVL UK - 2. LF a UK. Rozdělení - alkohol, stres, léky - akutní erozivní.
  4. The pathophysiology of SIRS is complex. There are a few elements that need to be emphasised. They are acute stress response, inflammatory process and cytokine storm. Firstly, stress response is the acute phrase reaction when the body tries to defence against the threatening triggers. Those triggers are also known as 'stress'
  5. utes a day for your relaxation practice. If that sounds like a daunting commitment, remember that many of these techniques can be incorporated into your existing daily schedule—practiced at your desk over lunch or on the bus during your morning commute

- Secondary traumatization stress or compassion stress: definition of trauma according ICD- 10 and DSM-5, causes of secondary traumatization stress, risk - factors, pathophysiology. Do paramedics more prone to stress at works and hence PTSD and depression because of compassion stress or compassion fatigue or secondary traumatization Finally, we summarize the pathophysiology of microvascular dysfunction emphasizing the role of oxidative stress and its regulation by epigenetic mechanisms, which might represent potential targets for novel interventions beyond conventional approaches, representing a new frontier in CV disease reduction

Stres (fyziologie) Knihy

  1. d and body. Until now, it has not been clear exactly how stress influences disease and health. Now researchers have found that chronic psychological stress is.
  2. Pathophysiology 3) Neuroendocrine hypothesis: • Dexamethasone supression test doesn't reduce cortisol level in 50% of depression patient; indicates imbalance in stress HPA axis (hypothalamus-pituitory- adrenal gland axis)
  3. Proposed role of stress-related hypothalamic-pituitary-adrenal (HPA) axis activation in the transition from acute to chronic pain. Acute stress response: pain or non-pain-related stressor activates a normal physiologic stress response (short-term sympathetic release of epinepherine and norepinepherine [E/NE] followed by secretion of the anti-inflammatory hormone, cortisol)
  4. The pathophysiology of myocardial infarction-induced heart failure Daniele Gabriel-Costa Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysi
  5. an stres Thursday, October 20, 2011. Pathophysiology Main articles: Carcinogenesis and The Hallmarks of Cancer. Cancers are caused by a series of mutations. Each mutation alters the behavior of the cell somewhat. Cancer is fundamentally a disease of failure of regulation of tissue growth

PATHOPHYSIOLOGY OF STRESS INCONTINENCE Abdominal Ke

The relationship between stress, heart disease and sudden death has been recognized since antiquity. The incidence of heart attacks and sudden death have been shown to increase significantly following the acute stress of natural disasters like hurricanes, earthquakes and tsunamis and as a consequence of any severe stressor that evokes fight or flight' responses If you find that you are stressed and not getting enough sleep, you're not alone.In a national sleep survey, 40 percent of respondents said they aren't getting the recommended amount of rest.   Many of the stressors we face in modern life, such as traffic jams, difficult co-workers, or relationship conflicts, can trigger a fight-or-flight response, and prolonged exposure to this stress. / RA Pathophysiology. RA Pathophysiology. Note: this is normally a very resilient tissue that absorbs considerable impact and stress. In RA, its integrity, resilience and water content are all impaired. This appears to be due to elaboration of proteolytic enzymes (collagenase, stromelysin) both by synovial lining cells and by chondrocytes.

Please use one of the following formats to cite this article in your essay, paper or report: APA. Mandal, Ananya. (2019, February 27). Psychosis Pathophysiology The pathophysiology is unclear but there are two hypothesis for discussion: periostitis induced by fascial traction or a local bone stress reaction. Internally a chronic inflammation of the muscular attachment along the posterior medial tibia and bony changes are considered to be the most likely cause of the medial tibial stress syndrome Syncope is a transient loss of consciousness secondary to inadequate cerebral perfusion with oxygenated blood. It is a common medical problem, accounting for around 5% of acute medical admissions and 3% of emergency department visits.1 Syncope secondary to cardiac causes carries the worst prognosis, with a one year mortality rate of 20-30%.2 An understanding of the events preceding syncope. Stres, stresová reakce, adaptace na opakovaný stres. b. Doporučení pohybového režimu ve středním věku. 5. a. Hypoxické stavy a jejich příčiny. statni-zaverecne-zkousce-z-patofyziologie-a-telovychovneho-lekarstvi. Title: Otázky ke státní závěrečné zkoušce z patofyziologie a tělovýchovného lékařstv A stable impacted stress fracture may present with chronic hip pain and immobility. Avascular necrosis or osteoarthritis can also be discovered accidentally during X-ray films. Note: The physical examination starts with an inspection of the skin for ecchymosis, any limb shortening or deformity, muscular atrophy or asymmetry, and any visible.

Understanding the stress response - Harvard Healt

Concise, up-to-date, faculty-reviewed articles on the pathophysiology of disease | Welcome to MPR Pathophysiology definition is - the physiology of abnormal states; specifically : the functional changes that accompany a particular syndrome or disease Oxidative stress is an imbalance of free radicals and antioxidants in the body, which can lead to cell and tissue damage. Oxidative stress occurs naturally and plays a role in the aging process Novel coronavirus disease (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its impact on patients with comorbidities is clearly related to fatality cases, and diabetes has been linked to one of the most important causes of severity and mortality in SARS-CoV-2 infected patients

Alkohol a stres? Z úniku před realitou se může stát

Stress fractures can occur in any active individual, from the weekend warrior to the elite athlete. As these injuries occur, it is important to understand how bones respond to the stresses placed on them. The understanding of potential intrinsic and extrinsic causes is important in treatment of these injuries. The proper identification and prevention of these stress injuries allows for. The stress fracture, first described by Breithaupt in 1855, is a common overuse injury seen in athletes and military recruits. The injury is usually seen in the lower extremities, but it has also been reported in the upper extremities and the ribs Pathophysiology. Part 1: Relationship between Concepts: Infection, Stress, & Cancer. Answer the following 2 questions completely and clearly as possible. Explain your thoughts and ideas fully. 1. What is the relationship of the concept of infection to the alteration that occurs at the cellular level, such as that happens in cancer? 2 Pathophysiology makes it easy for nurses to walk their patients through the process of testing, diagnosing, and treating their diseases. This practice test is based on the lecture outline for Introduction to Pathophysiology, and it consists of 53 most essential questions of the topic. So, let's get started

Ústav patologické fyziologie - Univerzita Karlov

  1. Takotsubo 'stress' cardiomyopathy is a non ischaemic cardiomyopathy commonly associated with stress or an emotive event, which may lead to acute HF. It is usually triggered by an emotional or physically stressful event and occurs more in woman over 50 years old than men
  2. Looks at how breathing exercises can help with stress relief. Includes step-by-step instructions for exercises like belly breathing, 4-7-8 breathing, and morning breathing. Offers links to more info on managing stress with guided imagery and meditation
  3. Stress has profound e ects on the structure and function of the brain at the cellular and subcellular levels. e impact of stress on brain structure and function is in uenced by a variety of factors including the duration and type of the stressor as well as age and sex of the animal [ ]. e major areas of the brain most a ected by stress are th
  4. Ik hoopje dat jo jo blogposten hawwe oer ferskate sûnens, nutriteits- en ferwûningsrelaasjes. Besykje jo net te freegjen by ús te roppen of sels as jo fragen hawwe as de soarch nedich is om te sykjen

implications for the pathophysiology of migraine. Neuronal calciumchannels mediate serotonin (5-HT) release within the midbrain (2). Therefore, dysfunction of these channels might impair serotonin release and predispose patients to migraine or impair their self-aborting mechanism. The interactions o Stress is a normal part of life that can either help us learn and grow or can cause us significant problems.; Stress releases powerful neurochemicals and hormones that prepare us for action (to fight or flee). If we don't take action, the stress response can create or worsen health problems Stress definition, importance attached to a thing: to lay stress upon good manners. See more This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The NIDDK translates and disseminates research findings to increase knowledge and understanding about health and disease among patients, health professionals, and the public Migraine is a common, multifactorial, disabling, recurrent, hereditary neurovascular headache disorder. It usually strikes sufferers a few times per year in childhood and then progresses to a few times per week in adulthood, particularly in females. Attacks often begin with warning signs (prodromes) and aura (transient focal neurological symptoms) whose origin is thought to involve the.

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